Quantitative Structure-Activity Relationship (QSAR) Modeling

  • Overview
  • Why Work With NSF

A quantitative structure-activity relationship (QSAR) is a predictive model for chemical effects. In these projects, NSF works to determine a mathematical relationship between the biological activity of a molecular system and its geometric and chemical characteristics to predict (either qualitatively or quantitatively) the physico-chemical, toxicological and environmental fate properties of chemicals.

QSAR modeling provides an alternative to some traditional methods, including animal testing. We can assess specific endpoints of toxicology concern without the necessity of additional in vitro or animal testing.

Why Work With NSF

NSF is an expert in the field, providing toxicology and chemical risk assessment services to evaluate ingredients, materials and products for nearly 30 years. NSF toxicologists have prepared more than 170 externally peer-reviewed chemical risk assessments and have populated a wide internal database of risk-based action levels for roughly 2,000 chemical contaminants.

Our toxicologists employ chemical hazard, exposure and risk assessment methodologies for evaluating the safety of food ingredients, drinking water products, food contact materials, dietary supplement ingredients/products and cosmetic and personal care products, and in support of safer chemistry and sustainability program initiatives.

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